The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function.

@article{Levesque2013TheRO,
  title={The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function.},
  author={Shannon Levesque and Thomas Taetzsch and Melinda E. Lull and Jo Anne Johnson and Constance McGraw and Michelle L. Block},
  journal={Journal of neurochemistry},
  year={2013},
  volume={125 5},
  pages={
          756-65
        }
}
Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial activation and Parkinson's disease-like pathology. To begin to address how DEP may exert CNS effects, microglia and neuron-glia cultures were treated with either nanometer-sized DEP (< 0.22 μM; 50 μg/mL), ultrafine carbon black (ufCB, 50 μg/mL), or DEP… CONTINUE READING

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