The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

  title={The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine},
  author={D. Weiner and H. Meltzer and I. Veinbergs and E. M. Donohue and T. Spalding and T. T. Smith and N. Mohell and S. C. Harvey and J. Lameh and N. Nash and K. Vanover and R. Olsson and K. Jayathilake and M. Lee and A. Levey and U. Hacksell and E. Burstein and R. Davis and M. Brann},
  • D. Weiner, H. Meltzer, +16 authors M. Brann
  • Published 2004
  • Medicine
  • Psychopharmacology
  • RationaleClozapine is a unique antipsychotic, with efficacy against positive symptoms in treatment-resistant schizophrenic patients, and the ability to improve cognition and treat the negative symptoms characteristic of this disease. Despite its unique clinical actions, no specific molecular mechanism responsible for these actions has yet been described.Objectives and methodsTo comprehensively profile a large library of neuropsychiatric drugs, including most antipsychotics, at human monoamine… CONTINUE READING
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