The role of LPA 1 in formation of synapses among cultured hippocampal neurons

@inproceedings{Pilpel2006TheRO,
  title={The role of LPA 1 in formation of synapses among cultured hippocampal neurons},
  author={Yair Pilpel and Menahem Segal},
  year={2006}
}
We studied the lysophosphatidic acid receptor-1 (LPA1) gene, which we found to be expressed endogenously in cultured hippocampal neurons, and in vivo in young (1-weekold) rat brain slices. Overexpressed green fluorescent protein (GFP)-tagged, membrane-associated LPA1 accumulated in a punctate manner over the entire dendritic tree and caused an increase in dendritic spine density. About half of the dendritic spines in the LPA1-transfected neurons displayed distinct fluorescent puncta, and this… CONTINUE READING