The role of L3T4+ cells in the pathogenesis of lupus in lpr-bearing mice. I. Defects in the production of interleukins 2 and 3.

Abstract

Mice which bear the lpr gene spontaneously develop autoimmune syndromes characterized by massive expansion of an unusual T cell subset which is phenotypically Thy-1+, L3T4-, Lyt-2-, B220+. The mutant T cells are refractory to stimulation with mitogenic lectins and, by implication, are thought to be solely responsible for the defects in lymphokine production… (More)

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@article{Santoro1987TheRO, title={The role of L3T4+ cells in the pathogenesis of lupus in lpr-bearing mice. I. Defects in the production of interleukins 2 and 3.}, author={T. J. Santoro and K. Lehmann and Ryan Batt and Brian L. Kotzin}, journal={European journal of immunology}, year={1987}, volume={17 8}, pages={1131-6} }