The role of L1 stalk-tRNA interaction in the ribosome elongation cycle.

@article{Trabuco2010TheRO,
  title={The role of L1 stalk-tRNA interaction in the ribosome elongation cycle.},
  author={Leonardo G. Trabuco and Eduard Schreiner and John Eargle and Peter V Cornish and Taekjip Ha and Zaida Luthey-Schulten and Klaus Schulten},
  journal={Journal of molecular biology},
  year={2010},
  volume={402 4},
  pages={741-60}
}
The ribosomal L1 stalk is a mobile structure implicated in directing tRNA movement during translocation through the ribosome. This article investigates three aspects of L1 stalk-tRNA interaction. First, by combining data from cryo electron microscopy, X-ray crystallography, and molecular dynamics simulations through the molecular dynamics flexible fitting method, we obtained atomic models of different tRNAs occupying the hybrid P/E state interacting with the L1 stalk. These models confirm the… CONTINUE READING

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