The role of JAM-A in inflammatory bowel disease: unrevealing the ties that bind.

@article{Vetrano2009TheRO,
  title={The role of JAM-A in inflammatory bowel disease: unrevealing the ties that bind.},
  author={Stefania Vetrano and Silvio Danese},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1165},
  pages={308-13}
}
Tight junctions (TJ) are junctional proteins whose function is to maintain an intact intestinal epithelial barrier and regulate the paracellular movement of water and solutes. Altered TJ structure and epithelial permeability are observed in inflammatory bowel disease and seem to have an important role in the pathogenesis of these diseases. Junctional adhesion molecule-A (JAM-A) is a protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes… CONTINUE READING

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