The role of IRES trans-acting factors in regulating translation initiation.

@article{King2010TheRO,
  title={The role of IRES trans-acting factors in regulating translation initiation.},
  author={Helen A King and Laura C. Cobbold and Anne E. Willis},
  journal={Biochemical Society transactions},
  year={2010},
  volume={38 6},
  pages={1581-6}
}
The majority of mRNAs in eukaryotic cells are translated via a method that is dependent upon the recognition of, and binding to, the methylguanosine cap at the 5' end of the mRNA, by a set of protein factors termed eIFs (eukaryotic initiation factors). However, many of the eIFs involved in this process are modified and become less active under a number of pathophysiological stress conditions, including amino acid starvation, heat shock, hypoxia and apoptosis. During these conditions, the… CONTINUE READING
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