The role of IL-21 in hematological malignancies.

  title={The role of IL-21 in hematological malignancies.},
  author={Jingjing Ma and Dao-xin Ma and Chunyan Ji},
  volume={56 2},
IL-21, the newest member of the common γ-chain family of cytokines, has pleiotropic biological effects through regulating a variety of immune cells. Recently, the role of IL-21 in the treatment of cancers has been widely investigated. Conducted phase I trials in metastatic malignant melanoma and renal cell carcinoma have shown that rIL-21 has a favorable antitumor activity. Expression of IL-21 and IL-21R has also been found in many types of hematological malignancies, such as chronic… CONTINUE READING


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