The role of IL-15 in gastrointestinal diseases: a bridge between innate and adaptive immune response.

@article{Pagliari2013TheRO,
  title={The role of IL-15 in gastrointestinal diseases: a bridge between innate and adaptive immune response.},
  author={Danilo Pagliari and Rossella Cianci and Simona Frosali and Raffaele Landolfi and Giovanni Cammarota and Estelle E. Newton and Franco Pandolfi},
  journal={Cytokine & growth factor reviews},
  year={2013},
  volume={24 5},
  pages={455-66}
}
IL-15 is a member of the IL-2 family of cytokines whose signaling pathways are a bridge between innate and adaptive immune response. IL-15 is part of the intestinal mucosal barrier, and functions to modulate gut homeostasis. IL-15 has pivotal roles in the control of development, proliferation and survival of both innate and adaptive immune cells. IL-15 becomes up-regulated in the inflamed tissue of intestinal inflammatory disease, such as IBD, Celiac Disease and related complications. Indeed… CONTINUE READING