The role of IL-12 in the induction of organ-specific autoimmune diseases.

Abstract

The concept that T cells are subdivided into T helper 1 (Th1) and Th2 subsets was recently extended to suggest that Th1 cells contribute to the pathogenesis of several organ-specific autoimmune diseases, whereas Th2 cells inhibit disease development. Here, Sylvie Trembleau and colleagues examine the role of interleukin 12 (IL-12), a key cytokine guiding the development of Th1 cells, in the induction of autoimmune diseases, and discuss potential immunointervention strategies based on administration of IL-12 antagonists.

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@article{Trembleau1995TheRO, title={The role of IL-12 in the induction of organ-specific autoimmune diseases.}, author={Sylvie Trembleau and Tiana M. Germann and Maurice K. Gately and L. Adorini}, journal={Immunology today}, year={1995}, volume={16 8}, pages={383-6} }