The role of IL-10 and IgG1 in the protection and granulomatous response in Schistosoma mansoni P24-immunized mice.

@article{Zouain2000TheRO,
  title={The role of IL-10 and IgG1 in the protection and granulomatous response in Schistosoma mansoni P24-immunized mice.},
  author={Cl{\'a}udia Soares Zouain and Shauma Gustavson and Sergio Costa Oliveira and Vasco Azevedo and Jos{\'e} Bento Alves and Alfredo de Miranda G{\'o}es},
  journal={Vaccine},
  year={2000},
  volume={19 9-10},
  pages={1218-24}
}
Previous work by our laboratory identified a fraction of Schistosoma mansoni soluble adult worm antigenic preparation, designated PIII, able to elicit significant in vitro cell proliferation, and lower in vitro and in vivo granuloma formation. In the present work, we investigated some biological activities of P24, an antigenic component of PIII. Immunization of mice with this antigen induced a significant protection degree against challenge infection and significant decrease in the hepatic… CONTINUE READING

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