The role of IL‐33 and its receptor ST2 in human nasal epithelium with allergic rhinitis

@article{Kamekura2012TheRO,
  title={The role of IL‐33 and its receptor ST2 in human nasal epithelium with allergic rhinitis},
  author={Ryuta Kamekura and Takashi Kojima and Kenichi Takano and Mitsuru Go and Norimasa Sawada and Tetsuo Himi},
  journal={Clinical \& Experimental Allergy},
  year={2012},
  volume={42}
}
Interleukin (IL)‐33 is a novel member of the IL‐1 cytokine family and a ligand for the orphan IL‐1 family receptor ST2. The IL‐33 induces T helper 2‐type inflammatory responses and is considered to play a crucial rule in allergic inflammations, such as asthma and atopic dermatitis. However, the role of IL‐33 and its receptor ST2 in allergic rhinitis remains unknown. 

Expression of IL‐33 and its receptor ST2 in chronic rhinosinusitis with nasal polyps

TLDR
The role of IL‐33 and its receptor ST2 in chronic rhinosinusitis remains unclear, but it is clear that it plays a crucial role in allergic inflammatory reactions.

Nasal levels of soluble IL‐33R ST2 and IL‐16 in allergic rhinitis: inverse correlation trends with disease severity

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Recent studies show that IL‐16, soluble ST2 or anti‐IL‐33 reduce type 2 cytokines (such as IL‐5) and eosinophilia in murine models of allergic asthma or allergic rhinitis respectively.

The Role of Interleukin-33 in Rhinitis

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Recent investigations regarding the IL-33/ST2 axis involvement in Th2 inflammatory response and pathogenesis of rhinitis have been reviewed and the role of IL- 33 as a novel promising therapeutic target has also been discussed.

Synergistic relationship between TSLP and IL‐33/ST2 signaling pathways in allergic rhinitis and the effects of hypoxia

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The aim of this study was to explore the relationship and expressions and biologic functions of TSLP and IL‐33/ST2 in AR, and also to determine the effects of hypoxia on these cytokines.

Interaction of thymic stromal lymphopoietin, IL‐33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

TLDR
Thymic stromal lymphopoietin (TSLP), IL‐25, and IL‐33 system contribute to the initiation and development of Th2 responses in chronic rhinosinusitis with nasal polyps and their cross‐regulation in human nasal epithelial cells (HNECs).

Interleukin-33: Its Emerging Role in Allergic Diseases

TLDR
The mobilization and biological function of IL-33 in allergic disorders is reviewed, providing novel insights for addressing these hypersensitive conditions.

The IL-33/ST2 axis: Role in health and disease.

Regulation of interleukin‐33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines

TLDR
This work investigated the signal transduction regulation of IL‐33 and TSLP induced by proinflammatory cytokines in nasal fibroblasts and found that these molecules regulated the regulation of epithelial cells and smooth muscle cells at nasal mucosal sites.

Increased expression of IL‐33 is found in the lower airways of patients with seasonal allergic rhinitis and is not related to natural allergen exposure

  • A. HaccuriaA. van Muylem A. Michils
  • Medicine, Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2021
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Evidence of a silent epithelial dysfunction in the airways of patient suffering from allergic rhinitis without asthma is provided, further confirming the «one airway, one disease» theory linking asthma and rhinita.

The role of type 2 innate lymphoid cells in asthma

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This work reviews the recent data regarding ILCs and their role in asthma, and newly described cell types that produce a variety of cytokines, including IL‐5 and IL‐13 are reviewed.
...

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