The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity

@article{Theofilopoulos2001TheRO,
  title={The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity},
  author={Argyrios N. Theofilopoulos and Stefanos Koundouris and Dwight H. Kono and Brian R. Lawson},
  journal={Arthritis Research},
  year={2001},
  volume={3},
  pages={136 - 141}
}
The classification of T helper cells into type 1 (Th1) and type 2 (Th2) led to the hypothesis that Th1 cells and their cytokines (interleukin [IL]-2, interferon [IFN]-gamma) are involved in cell-mediated autoimmune diseases, and that Th2 cells and their cytokines (IL-4, IL-5, IL-10, IL-13) are involved in autoantibody(humoral)-mediated autoimmune diseases. However, this paradigm has been refuted by recent studies in several induced and spontaneous mouse models of systemic lupus erythematosus… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

Innate lymphoid cell-derived cytokines in autoimmune diseases.

Sirui Li, Di Yang, +3 authors Bing Ni
Journal of autoimmunity • 2017
View 20 Excerpts
Highly Influenced

T Cell-Associated Cytokines in the Pathogenesis of Sjögren's Syndrome.

Journal of clinical & cellular immunology • 2013
View 8 Excerpts
Highly Influenced

Oryzatensin-stimulated PBMCs Increase Cancer Progression In-vitro.

Iranian journal of allergy, asthma, and immunology • 2017
View 1 Excerpt

The Increased Expression of Toll-Like Receptor 4 in Renal and Skin Lesions in Lupus Erythematosus.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society • 2017

References

Publications referenced by this paper.
Showing 1-10 of 69 references

Complexity or coherence? Cytokine secretion by B cells

Nature Immunology • 2000
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…