The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage

@inproceedings{Agmon2011TheRO,
  title={The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage},
  author={Neta Agmon and Moran Yovel and Yaniv Harari and Batia Liefshitz and Martin Kupiec},
  booktitle={Nucleic acids research},
  year={2011}
}
DNA double-strand breaks (DSBs) and other lesions occur frequently during cell growth and in meiosis. These are often repaired by homologous recombination (HR). HR may result in the formation of DNA structures called Holliday junctions (HJs), which need to be resolved to allow chromosome segregation. Whereas HJs are present in most HR events in meiosis, it has been proposed that in vegetative cells most HR events occur through intermediates lacking HJs. A recent screen in yeast has shown HJ… CONTINUE READING