The role of His-18 in amyloid formation by human islet amyloid polypeptide.

@article{Abedini2005TheRO,
  title={The role of His-18 in amyloid formation by human islet amyloid polypeptide.},
  author={Andisheh Abedini and Daniel P Raleigh},
  journal={Biochemistry},
  year={2005},
  volume={44 49},
  pages={16284-91}
}
The 37-residue islet amyloid polypeptide (IAPP) is the major protein component of the amyloid deposits found in type-II diabetes. IAPP is stored in a relatively low pH environment in the pancreatic secretory granules prior to its release to the extracellular environment. Human IAPP contains a single histidine at position 18. Aggregation of IAPP is considerably faster at a lower pH (4.0 +/- 0.3) than at high pH (8.8 +/- 0.3), as judged by turbidity and thioflavine-T fluorescence studies. The… CONTINUE READING

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