The role of Hedgehog signaling in fibrogenic liver repair.

@article{Choi2011TheRO,
  title={The role of Hedgehog signaling in fibrogenic liver repair.},
  author={Steve Choi and Alessia Omenetti and Wing-Kin Syn and Anna Mae Diehl},
  journal={The international journal of biochemistry & cell biology},
  year={2011},
  volume={43 2},
  pages={238-44}
}
Repair of adult liver, like many tissues, involves the coordinated response of a number of different cell types. In adult livers, fibroblastic cells, ductular cells, inflammatory cells, and progenitor cells contribute to this process. Our studies demonstrate that the fates of such cells are dictated, at least in part, by Hedgehog, a fetal morphogenic pathway that was once thought to be active mainly during embryogenesis. Studies of injured adult human and rodent livers demonstrate that injury… CONTINUE READING

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