The role of HSP27 in RACK1-mediated PKC activation in THP-1 cells.

@article{Corsini2016TheRO,
  title={The role of HSP27 in RACK1-mediated PKC activation in THP-1 cells.},
  author={Emanuela Corsini and Valentina Galbiati and Angela Papale and Elena Kummer and Antonella Pinto and Antonio Guaita and Marco Racchi},
  journal={Immunologic research},
  year={2016},
  volume={64 4},
  pages={940-50}
}
Receptor for Activated C Kinase 1 (RACK1) pseudosubstrate is a commercially available peptide that directly activates protein kinase C-β (PKCβ). We have recently shown that RACK1 pseudosubstrate, alone or in combination with classical immune activators, results in increased cytokine production and CD86 upregulation in primary leukocytes. Furthermore, we demonstrated a role of PKCβ and RACK1 in chemical allergen-induced CD86 expression and IL-8 production in both THP-1 cells and primary human… CONTINUE READING
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