The role of HMGB1 in heart transplantation.

  title={The role of HMGB1 in heart transplantation.},
  author={Qianying Lv and Chao Li and Yarui Mo and Long He},
  journal={Immunology letters},
There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of heart allograft rejection. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived innate immune activators that have multiple functions in the… CONTINUE READING