The role of HLA-B27 polymorphism and molecular mimicry in spondylarthropathy.

  title={The role of HLA-B27 polymorphism and molecular mimicry in spondylarthropathy.},
  author={C. Lopez-Larrea and Soledad Natalia Gonzalez and Jes{\'u}s Mart{\'i}nez-Borra},
  journal={Molecular medicine today},
  volume={4 12},
Ankylosing spondylitis (AS), reactive arthritis (ReA) and other related spondyloarthropathies (SpAs) are characterized by a strong association with the major histocompatibility complex allele HLA-B27. Experimental evidence from humans and transgenic rodents suggests that HLA-B27 is itself involved in the pathogenesis of SpA. Population and peptide-specificity analysis of HLA-B27 suggest it has a pathogenic function related to antigen presentation. Putative roles for infectious agents have been… CONTINUE READING
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