The role of HIF1α in renal cell carcinoma tumorigenesis

@article{Gudas2014TheRO,
  title={The role of HIF1α in renal cell carcinoma tumorigenesis},
  author={Lorraine J Gudas and Leiping Fu and Denise R. Minton and Nigel P. Mongan and David M. Nanus},
  journal={Journal of Molecular Medicine},
  year={2014},
  volume={92},
  pages={825-836}
}
  • Lorraine J Gudas, Leiping Fu, +2 authors David M. Nanus
  • Published in Journal of Molecular Medicine 2014
  • Medicine, Biology
  • The transcription factor HIF1α is implicated in the development of clear cell renal cell carcinoma (ccRCC). Although HIF1α was initially believed to be essential for ccRCC development, recent studies hypothesize an oncogenic role for HIF2α in ccRCC, but a tumor suppressor role for HIF1α [1], leading to uncertainty as to the precise roles of the different HIF transcription factors in this disease. Using evidence available from studies with human ccRCC cell lines, mouse xenografts, murine models… CONTINUE READING

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