The role of H-2-linked genes in helper T-cell function. I. In vitro expression in B cells of immune response genes controlling helper T-cell activity

@article{Kappler1977TheRO,
  title={The role of H-2-linked genes in helper T-cell function. I. In vitro expression in B cells of immune response genes controlling helper T-cell activity},
  author={J W Kappler and Philippa Marrack},
  journal={The Journal of Experimental Medicine},
  year={1977},
  volume={146},
  pages={1748 - 1764}
}
The ability of murine helper T cells primed to the antigen, sheep erythrocytes (SRBC) to cross-react with burro erythrocytes (BRBC) in the in vitro anti-trinitrophenol (TNP) response to TNP-RBC was shown to be under genetic control. Although non-H-2 genes were shown to influence the absolute level of helper activity assayed after SRBC priming, the extent of cross-reaction of SRBC-primed helpers with BRBC was shown to be controlled by an H-2-1inked Ir gene(s). H-2 haplotypes were identified… CONTINUE READING
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Immunization of dissociated spleen cell cultures from normal mice

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Simultaneous recognition of carrier antigens and products of the H-2 complex by helper T cells

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Highly Influential
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