The role of GW/P-bodies in RNA processing and silencing.

@article{Jakymiw2007TheRO,
  title={The role of GW/P-bodies in RNA processing and silencing.},
  author={Andrew Jakymiw and Kaleb M. Pauley and Songqing Li and Keigo Ikeda and Shangli Lian and Theophany Eystathioy and Minoru Satoh and Marvin J Fritzler and Edward K. L. Chan},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 8},
  pages={
          1317-23
        }
}
GW bodies, also known as mammalian P-bodies, are cytoplasmic foci involved in the post-transcriptional regulation of eukaryotic gene expression. Recently, GW bodies have been linked to RNA interference and demonstrated to be important for short-interfering-RNA- and microRNA-mediated mRNA decay and translational repression. Evidence indicates that both passenger and guide strands of short-interfering RNA duplexes can localize to GW bodies, thereby indicating that RNA-induced silencing complexes… CONTINUE READING

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