The role of GABA and anxiety in the reconsolidation of conditioned fear.

@article{Zhang2008TheRO,
  title={The role of GABA and anxiety in the reconsolidation of conditioned fear.},
  author={Shirley Q Zhang and Jacquelyn Cranney},
  journal={Behavioral neuroscience},
  year={2008},
  volume={122 6},
  pages={
          1295-305
        }
}
The current study examined the effects of systemic administration of a GABA agonist [midazolam (MDZ)] and a GABA antagonist (bicuculline) on fear responding after brief CS exposure, a procedure thought to involve memory reconsolidation. Using a contextual fear-conditioning paradigm, rats were initially given two context-shock training trials, followed 24 hrs later by a 90-s context exposure (reactivation), and 24 hrs later by a 3-min context test. In Experiment 1, MDZ (2 mg/kg, i.p.), whereas… 
Previous Stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration
TLDR
The results show that MDZ did not affect memory reconsolidation in older-than-one-day memories of stressed animals, even after the administration of a higher MDZ dose and a longer reactivation session, and indicate that DCS before reactivation promotes retrieval-induced lability in resistant memory traces, as MDZ-induced memory impairment in stressed rats became evident with pre-reactivation DCS but not after pre- reactivation sterile isotonic saline.
The Effect of Propranolol and Midazolam on the Reconsolidation of a Morphine Place Preference in Chronically Treated Rats
TLDR
Propranolol and midazolam disrupted reconsolidation in morphine-naïve rats, but failed to disrupt the CPP when rats were trained under chronic morphine treatment, even if they were recovered from chronic opiate exposure before reactivation.
Reconsolidation of a morphine place preference: Impact of the strength and age of memory on disruption by propranolol and midazolam
Reactivation of memories may render them labile and subject to disruption by amnestic drugs thus reducing their impact on future behavior, but whether it is possible with well-established memories is
The Effect of Midazolam and Propranolol on Fear Memory Reconsolidation in Ethanol-Withdrawn Rats: Influence of D-Cycloserine
TLDR
The resistance to MDZ’s disruptive effect on fear memory reconsolidation may be, at least in part, associated with changes in the GABAA-R composition induced by chronic ethanol administration/withdrawal.
Benzodiazepine treatment can impair or spare extinction, depending on when it is given.
TLDR
It is suggested that the effectiveness of extinction will not be reduced when combined with a benzodiazepine if the patient has undergone some initial extinction drug-free.
Behavioral and Neural Analysis of GABA in the Acquisition, Consolidation, Reconsolidation, and Extinction of Fear Memory
TLDR
The evidence implies that the processes mediating memory stability consequent to initial fear learning, memory reactivation, and extinction training are dependent on a common mechanism of reduced GABAergic neurotransmission.
The CB1 Receptor Antagonist AM251 Impairs Reconsolidation of Pavlovian Fear Memory in the Rat Basolateral Amygdala
TLDR
Data show that the endocannabinoid system in the BLA is an important modulator of fear memory reconsolidation and that its effects on memory are mediated by an interaction with the GABAergic system, which may have therapeutic potential to reduce the impact of maladaptive memories in neuropsychiatric disorders such as posttraumatic stress disorder.
Gastrin-releasing peptide attenuates fear memory reconsolidation
TLDR
GRP significantly attenuated the reconsolidation of learned fear when administered immediately (but not 10 min or longer) following recall, suggesting the effect is mediated via a GABAergic mechanism.
Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation
TLDR
The data suggest that strong emotional memories are capable of updating following weakening of memory expression through extinction, and that rats that received tone extinction underwent tone memory reconsolidation following its renewal.
Limited replicability of drug-induced amnesia after contextual fear memory retrieval in rats
TLDR
The results suggest that post-reactivation amnesia by systemic drug administration in rats is more difficult to obtain than what would be expected based on published empirical reports.
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