The role of GABA and anxiety in the reconsolidation of conditioned fear.

@article{Zhang2008TheRO,
  title={The role of GABA and anxiety in the reconsolidation of conditioned fear.},
  author={Shirley Q Zhang and Jacquelyn Cranney},
  journal={Behavioral neuroscience},
  year={2008},
  volume={122 6},
  pages={
          1295-305
        }
}
The current study examined the effects of systemic administration of a GABA agonist [midazolam (MDZ)] and a GABA antagonist (bicuculline) on fear responding after brief CS exposure, a procedure thought to involve memory reconsolidation. Using a contextual fear-conditioning paradigm, rats were initially given two context-shock training trials, followed 24 hrs later by a 90-s context exposure (reactivation), and 24 hrs later by a 3-min context test. In Experiment 1, MDZ (2 mg/kg, i.p.), whereas… 

Figures and Tables from this paper

Previous Stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration
TLDR
The results show that MDZ did not affect memory reconsolidation in older-than-one-day memories of stressed animals, even after the administration of a higher MDZ dose and a longer reactivation session, and indicate that DCS before reactivation promotes retrieval-induced lability in resistant memory traces, as MDZ-induced memory impairment in stressed rats became evident with pre-reactivation DCS but not after pre- reactivation sterile isotonic saline.
The Effect of Propranolol and Midazolam on the Reconsolidation of a Morphine Place Preference in Chronically Treated Rats
TLDR
Propranolol and midazolam disrupted reconsolidation in morphine-naïve rats, but failed to disrupt the CPP when rats were trained under chronic morphine treatment, even if they were recovered from chronic opiate exposure before reactivation.
The Effect of Midazolam and Propranolol on Fear Memory Reconsolidation in Ethanol-Withdrawn Rats: Influence of D-Cycloserine
TLDR
The resistance to MDZ’s disruptive effect on fear memory reconsolidation may be, at least in part, associated with changes in the GABAA-R composition induced by chronic ethanol administration/withdrawal.
Behavioral and Neural Analysis of GABA in the Acquisition, Consolidation, Reconsolidation, and Extinction of Fear Memory
TLDR
The evidence implies that the processes mediating memory stability consequent to initial fear learning, memory reactivation, and extinction training are dependent on a common mechanism of reduced GABAergic neurotransmission.
The CB1 Receptor Antagonist AM251 Impairs Reconsolidation of Pavlovian Fear Memory in the Rat Basolateral Amygdala
TLDR
Data show that the endocannabinoid system in the BLA is an important modulator of fear memory reconsolidation and that its effects on memory are mediated by an interaction with the GABAergic system, which may have therapeutic potential to reduce the impact of maladaptive memories in neuropsychiatric disorders such as posttraumatic stress disorder.
Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation
TLDR
The data suggest that strong emotional memories are capable of updating following weakening of memory expression through extinction, and that rats that received tone extinction underwent tone memory reconsolidation following its renewal.
...
1
2
3
4
...

References

SHOWING 1-10 OF 66 REFERENCES
Midazolam disrupts fear memory reconsolidation
Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats
TLDR
The results suggest that SPS can reproduce behavioral alteration similar to that observed in patients with PTSD, and this elevated fear response can be alleviated by the chronic administration of PRX at doses producing clinically relevant serum concentrations.
Reconsolidation and Extinction of Conditioned Fear: Inhibition and Potentiation
TLDR
Investigation of the effects of enhancing and blocking NMDA receptor-mediated glutamatergic transmission on the reconsolidation and extinction of a conditioned fear memory showed that the basolateral amygdala is a primary locus of action of systemically administered DCS, and memory reconsolidations can be both disrupted and enhanced.
Enhancement of conditioned fear extinction by infusion of the GABAA agonist muscimol into the rat prefrontal cortex and amygdala
TLDR
A facilitating role is proposed for GABAA neurotransmission in the IL in triggering the onset of fear extinction and its maintenance, whereas in the BLA, GAB AA neurotransmission facilitates extinction consolidation.
Evidence that GABA transmission mediates context-specific extinction of learned fear
TLDR
The present findings indicate that GABA transmission at GABAA receptors is involved in the inhibition of extinguished fear, and that this effect of GABA is regulated by those cues that constitute the extinction context.
NMDA Partial Agonist Reverses Blocking of Extinction of Aversive Memory by GABAA Agonist in the Amygdala
  • I. Akirav
  • Biology, Psychology
    Neuropsychopharmacology
  • 2007
TLDR
The aim was to further explore the interaction between GABA and NMDA in the amygdala in consolidation of experimental extinction in the rat and find that microinfusing the partial NMDA agonist D-cycloserine together with or after muscimol infusion reversed the blocking effects of muscicimol.
Enhancement of extinction memory consolidation: The role of the noradrenergic and GABAergic systems within the basolateral amygdala
D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement.
TLDR
Questions are raised about the mechanisms underlying DCS facilitation of extinction and the results suggest that DCS might have substantial practical benefit.
Effects of D-cycloserine on extinction of conditioned freezing.
TLDR
The results suggest that DCS facilitates extinction of conditioned freezing by acting on consolidation processes partly mediated by the basolateral amygdala, and the dose-response curve for this effect was linear.
Effects of post-training bicuculline and muscimol on retention: lack of state dependency.
...
1
2
3
4
5
...