The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.

@article{Lodowski2005TheRO,
  title={The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.},
  author={David T. Lodowski and Jennifer F Barnhill and Robyn M Pyskadlo and Rodolfo Ghirlando and Rachel Sterne-Marr and John J G Tesmer},
  journal={Biochemistry},
  year={2005},
  volume={44 18},
  pages={6958-70}
}
In response to extracellular signals, G protein-coupled receptors (GPCRs) catalyze guanine nucleotide exchange on Galpha subunits, enabling both activated Galpha and Gbetagamma subunits to target downstream effector enzymes. One target of Gbetagamma is G protein-coupled receptor kinase 2 (GRK2), an enzyme that initiates homologous desensitization by… CONTINUE READING