The role of FSH and TGF-β superfamily in follicle atresia

@inproceedings{Chu2018TheRO,
  title={The role of FSH and TGF-β superfamily in follicle atresia},
  author={Yu-Lan Chu and Ya-ru Xu and Wan-Xi Yang and Yi Sun},
  booktitle={Aging},
  year={2018}
}
Most of the mammalian follicles undergo a degenerative process called "follicle atresia". Apoptosis of granulosa cells is the main characteristic of follicle atresia. Follicle stimulating hormone (FSH) and the transforming growth factor β (TGF-β) superfamily have important regulatory functions in this process. FSH activates protein kinase A and cooperating with insulin receptor substrates, it promotes the PI3K/Akt pathway which weakens apoptosis. Both Smad or non-Smad signaling of the… CONTINUE READING

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