The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

  title={The role of FOXO1 in β-cell failure and type 2 diabetes mellitus},
  author={Tadahiro Kitamura},
  journal={Nature Reviews Endocrinology},
Over the past two decades, insulin resistance has been considered essential to the aetiology of type 2 diabetes mellitus (T2DM). However, insulin resistance does not lead to T2DM unless it is accompanied by pancreatic β-cell dysfunction, because healthy β cells can compensate for insulin resistance by increasing in number and functional output. Furthermore, β-cell mass is decreased in patients with diabetes mellitus, suggesting a primary role for β-cell dysfunction in the pathogenesis of T2DM… CONTINUE READING
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