The role of FGF23 in CKD—with or without Klotho

  title={The role of FGF23 in CKD—with or without Klotho},
  author={Hirotaka Komaba and Masafumi Fukagawa},
  journal={Nature Reviews Nephrology},
During the past few years, fibroblast growth factor 23 (FGF23) has emerged as a central player of disordered mineral metabolism in patients with chronic kidney disease (CKD). The physiological actions of FGF23 are to promote phosphaturia, decrease production of 1,25-dihydroxyvitamin D and suppress secretion of parathyroid hormone mediated through FGF… CONTINUE READING