The role of FGF signaling in the establishment and maintenance of mesodermal gene expression in Xenopus.

@article{Fletcher2008TheRO,
  title={The role of FGF signaling in the establishment and maintenance of mesodermal gene expression in Xenopus.},
  author={Russell B. Fletcher and Richard M Harland},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 5},
  pages={1243-54}
}
FGF signaling is important for the formation of mesoderm in vertebrates, and when it is perturbed in Xenopus, most trunk and tail mesoderm fails to form. Here we have further dissected the activities of FGF in patterning the embryo by addressing its inductive and maintenance roles. We show that FGF signaling is necessary for the establishment of xbra expression in addition to its well-characterized role in maintaining xbra expression. The role of FGF signaling in organizer formation is not… CONTINUE READING

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