The role of FGF/Erk signaling in pluripotent cells.

@article{Lanner2010TheRO,
  title={The role of FGF/Erk signaling in pluripotent cells.},
  author={Fredrik Lanner and Janet Rossant},
  journal={Development},
  year={2010},
  volume={137 20},
  pages={
          3351-60
        }
}
Fibroblast growth factor (FGF) signaling controls fundamental processes such as proliferation, differentiation and migration throughout mammalian development. Here we discuss recent discoveries that implicate FGF/Erk signaling in the control of pluripotency and lineage specification in several different stem cell states, including the separation of pluripotent epiblast and primitive endoderm in the blastocyst, the lineage priming of embryonic stem (ES) cells, and in the stabilization of the… CONTINUE READING

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