The role of ESCRT proteins in attenuation of cell signalling.


The ESCRT (endosomal sorting complex required for transport) machinery consists of four protein complexes that mediate sorting of ubiquitinated membrane proteins into the intraluminal vesicles of multivesicular endosomes, thereby targeting them for degradation in lysosomes. In the present paper, we review how ESCRT-mediated receptor down-regulation affects signalling downstream of Notch and growth factor receptors, and how ESCRTs may control cell proliferation, survival and cytoskeletal functions and contribute to tumour suppression.

DOI: 10.1042/BST0370137

Cite this paper

@article{Rodahl2009TheRO, title={The role of ESCRT proteins in attenuation of cell signalling.}, author={Lina M.W. Rodahl and Susanne Stuffers and Viola H{\'e}l{\`e}ne Lobert and Harald Stenmark}, journal={Biochemical Society transactions}, year={2009}, volume={37 Pt 1}, pages={137-42} }