The role of ER stress-induced apoptosis in neurodegeneration.

  title={The role of ER stress-induced apoptosis in neurodegeneration.},
  author={Ioanna C Stefani and Daniel M Wright and Karen M Polizzi and Cleo Kontoravdi},
  journal={Current Alzheimer research},
  volume={9 3},
Post-mortem analyses of human brain tissue samples from patients suffering from neurodegenerative disorders have demonstrated dysfunction of the endoplasmic reticulum (ER). A common characteristic of the aforementioned disorders is the intracellular accumulation and aggregation of proteins due to genetic mutations or exogenous factors, leading to the… CONTINUE READING