The role of EKLF in human beta-globin gene competition.

  title={The role of EKLF in human beta-globin gene competition.},
  author={Mark G J M Wijgerde and J Gribnau and Tolleiv Trimborn and Beatriz Nuez and Sjaak Philipsen and Frank Grosveld and Peter Fraser},
  journal={Genes & development},
  volume={10 22},
We have investigated the role of erythroid Kruppel-like factor (EKLF) in expression of the human beta-globin genes in compound EKLF knockout/human beta-locus transgenic mice. EKLF affects only the adult mouse beta-globin genes in homozygous knockout mice; heterozygous mice are unaffected. Here we show that EKLF knockout mice express the human epsilon and gamma-globin genes normally in embryonic red cells. However, fetal liver erythropoiesis, which is marked by a period of gamma- and beta-gene… CONTINUE READING


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