The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage.

@article{Pannone2014TheRO,
  title={The role of E-cadherin down-regulation in oral cancer: CDH1 gene expression and epigenetic blockage.},
  author={Giuseppe Pannone and Angela Santoro and Antonia Feola and Pantaleo Bufo and Petros Papagerakis and Lorenzo Lo Muzio and Stefania Staibano and Franco Ionna and Francesco Longo and Renato Franco and Gabriella Aquino and Mar{\'i}a Contaldo and Salvatore de Maria and Rosario Serpico and Alfredo De Rosa and Corrado Rubini and Silvana Papagerakis and Alfonso Giovane and Vincenzo Tombolini and Anthony Giordano and Michele Caraglia and Marina Di Domenico},
  journal={Current cancer drug targets},
  year={2014},
  volume={14 2},
  pages={115-27}
}
BACKGROUND The prognosis of the oral squamous cell carcinoma (OSCC) patients remains very poor, mainly due to their high propensity to invade and metastasize. E-cadherin reduced expression occurs in the primary step of oral tumour progression and gene methylation is a mode by which the expression of this protein is regulated in cancers. In this perspective, we investigated E-cadherin gene (CDH1) promoter methylation status in OSCC and its correlation with Ecadherin protein expression… CONTINUE READING
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