The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes

@article{Maki1981TheRO,
  title={The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes},
  author={Richard A Maki and W D Roeder and Andr{\'e} Traunecker and Charles L. Sidman and Matthias R. Wabl and William C. Raschke and Susumu Tonegawa},
  journal={Cell},
  year={1981},
  volume={24},
  pages={353-365}
}
We have established the exon-intron structure of the gene coding for the constant (C) region of the mouse immunoglobulin delta heavy chain, using DNA clones isolated from BALB/c embryos and the delta mRNA extracted from two delta-producing hybridomas, B1-8. delta 1 and GCL2.8. At least three types of C delta gene structures are identified. A 2.7 kb delta mRNA reveals six exons. This delta mRNA may code for a membrane-bound delta chain. A second delta mRNA of 1.8 kb shares the first (5' side… 
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TRANSCRIPTIONAL REGULATION OF THE ~-~ HEAVY CHAIN LOCUS IN NORMAL
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