The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.

@article{Bethke2007TheRO,
  title={The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.},
  author={Lara L Bethke and Susan L Thomas and Kerone Walker and Ronak Lakhia and Radha Rangarajan and Dyann Wirth},
  journal={Molecular and biochemical parasitology},
  year={2007},
  volume={155 1},
  pages={18-25}
}
Although the mechanisms by which malaria parasites develop resistance to drugs are unclear, current knowledge suggests a main mechanism of resistance is the alteration of target enzymes by point mutation. In other organisms, defects in DNA mismatch repair have been linked to increased mutation rates and drug resistance. We have identified an unusual complement of mismatch repair genes in the Plasmodium genome. An initial functional test of two of these genes (PfMSH2-1 and PfMSH2-2) using a… CONTINUE READING

From This Paper

Topics from this paper.
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…