The role of DNA deformation energy at individual base steps for the identification of DNA-protein binding sites.

@article{Steffen2002TheRO,
  title={The role of DNA deformation energy at individual base steps for the identification of DNA-protein binding sites.},
  author={Nicholas R. Steffen and S. D. Murphy and Richard H. Lathrop and Michael L. Opel and L. Tolleri and G. Wesley Hatfield},
  journal={Genome informatics. International Conference on Genome Informatics},
  year={2002},
  volume={13},
  pages={153-62}
}
We examine the use of deformation propensity at individual base steps for the identification of DNA-protein binding sites. We have previously demonstrated that estimates of the total energy to bend DNA to its bound conformation can partially explain indirect DNA-protein interactions. We now show that the deformation propensities at each base step are not equally informative for classifying a sequence as a binding site, and that applying non-uniform weights to the contribution of each base step… CONTINUE READING
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An interdisciplinary approach employing computational, biochemical, and genomic methods to examine the effects of chromosome structure on the regulation of gene expression

  • L. Tolleri
  • Ph.D. Thesis, Universita degli Studi di Pavia e…
  • 2002
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