The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases

@inproceedings{Jani2014TheRO,
  title={The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases},
  author={Meghna Jani and Anne Barton and Richard B Warren and Christopher Griffiths and Hector Chinoy},
  booktitle={Rheumatology},
  year={2014}
}
The management of RA, SpA, psoriasis and inflammatory bowel disease has significantly improved over the last decade with the addition of tumour necrosis factor inhibitors (anti-TNFs) to the therapeutic armamentarium. Immunogenicity in response to monoclonal antibody therapies (anti-drug antibodies) may give rise to low serum drug levels, loss of therapeutic response, poor drug survival and/or adverse events such as infusion reactions. To combat these, the use of concomitant MTX may attenuate… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Similar Papers

Loading similar papers…