The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.

@article{Sawatani2008TheRO,
  title={The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.},
  author={Yumi Sawatani and Takeshi Miyamoto and Shigenori E. Nagai and Mikako Maruya and Jun Imai and Kazutaka Miyamoto and Nobuyuki Fujita and Ken Ninomiya and Toru Suzuki and Ryotaro Iwasaki and Yoshiaki Toyama and Masanori Shinohara and Shigeo Koyasu and Toshio Suda},
  journal={International immunology},
  year={2008},
  volume={20 10},
  pages={
          1259-68
        }
}
Regulation of dendritic cell (DC) function is critical for maintaining self-tolerance and preventing autoimmunity. The dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in cell-cell fusion of osteoclasts and foreign body giant cells, but though originally identified in DCs, its specific roles there remain undefined. Here, we report that aged DC-STAMP-deficient mice display several systemic autoimmune symptoms such as spontaneous lymphoproliferation, splenomegaly… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Dendritic Cells: Cellular Mediators for Immunological Tolerance

  • Clinical & developmental immunology
  • 2013
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Characterization of DC-STAMP+ Cells in Human Bone Marrow

  • Journal of bone marrow research
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Similar Papers