• DOI:10.1517/14728222.6.4.423
Corpus ID: 21541850

The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?

@article{Baribaud2002TheRO,
  title={The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?},
  author={F. Baribaud and R. Doms and S. P{\"o}hlmann},
  journal={Expert Opinion on Therapeutic Targets},
  year={2002},
  volume={6},
  pages={423 - 431}
}

F. Baribaud, R. Doms, S. Pöhlmann

Published 2002

Biology, Medicine

Expert Opinion on Therapeutic Targets

Sexual transmission of HIV requires that the virus crosses mucosal barriers and disseminates into lymphoid tissue, the major site of viral replication. To achieve this, HIV might engage DC-SIGN, a calcium dependent lectin that is expressed on mucosal dendritic cells (DCs), which binds avidly to HIV. DC-SIGN and other attachment factors are likely to account for the well-known ability of DCs to enhance infection of T cells by HIV. Attachment of HIV to DC-SIGN might thus enhance viral spread in… CONTINUE READING

View on Taylor & Francis

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed