The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?

@article{Baribaud2002TheRO,
  title={The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?},
  author={Fr{\'e}d{\'e}ric Baribaud and Robert W. Doms and Stefan P{\"o}hlmann},
  journal={Expert Opinion on Therapeutic Targets},
  year={2002},
  volume={6},
  pages={423 - 431}
}
Sexual transmission of HIV requires that the virus crosses mucosal barriers and disseminates into lymphoid tissue, the major site of viral replication. To achieve this, HIV might engage DC-SIGN, a calcium dependent lectin that is expressed on mucosal dendritic cells (DCs), which binds avidly to HIV. DC-SIGN and other attachment factors are likely to account for the well-known ability of DCs to enhance infection of T cells by HIV. Attachment of HIV to DC-SIGN might thus enhance viral spread in… 
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54 Citations
Highly Influential Citations
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54 Citations

A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance.
Covert Human Immunodeficiency Virus Replication in Dendritic Cells and in DC-SIGN-Expressing Cells Promotes Long-Term Transmission to Lymphocytes
TLDR
It is demonstrated that transfer of incoming virions from iDCs or DC-SIGN+ cells occurs only on the short-term (i.e., a few hours after viral exposure), and there is no long-term storage of original HIV particles in these cells.
DC-SIGN: binding receptor for HCV?
TLDR
Clinical strategies that target DC-SIGN may be successful in restricting HCV dissemination and pathogenesis as well as directing the migration of DCs to manipulate appropriate immune responses in autoimmunity and tumorigenic situations.
West Nile Virus Discriminates between DC-SIGN and DC-SIGNR for Cellular Attachment and Infection
TLDR
It was discovered thatDC-SIGNR promoted WNV infection much more efficiently than did DC-SIGN, particularly when the virus was grown in human cell types, believed to be the first report of a pathogen interacting more efficiently with DC- SIGNR than with D-SIGN.
PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection
TLDR
The results suggest that PPARγ and LXR signaling up-regulate ABCA1-mediated cholesterol efflux from DCs and that this accounts for the decreased ability of DCs to capture HIV-1.
DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets
TLDR
It is shown that platelets express both the C-type lectin-like receptor 2 (CLEC-2) and low levels of DC-SIGN, indicating that these lectins are required for efficient HIV-1 binding to platelets and providing evidence that platelet-associated virus remains infectious and can escape degradation by platelets.
Evidence that multiple defects in murine DC-SIGN inhibit a functional interaction with pathogens
Cell‐surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus
TLDR
The early stages of infection of MΦ and DC by IAV are reviewed and the potential role of CLRs expressed on MΧ and DC to act as attachment and/or entry receptors for IAV is examined.
Dendritic Cells/Macrophages-Targeting Feature of Ebola Glycoprotein and its Potential as Immunological Facilitator for Antiviral Vaccine Approach
TLDR
The unique features of EBOV GP to target the DC, and its potential to elicit strong immune responses while targeting DCs/macrophages are discussed.
The Signal Peptide of the Ebolavirus Glycoprotein Influences Interaction with the Cellular Lectins DC-SIGN and DC-SIGNR
TLDR
The results suggest that the signal peptide governs EBOv-GP interactions with DC-SIGN/R by modulating the incorporation of high-mannose carbohydrates into EBOV-GP.
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References

SHOWING 1-10 OF 72 REFERENCES
Quantitative Expression and Virus Transmission Analysis of DC-SIGN on Monocyte-Derived Dendritic Cells
TLDR
It is found that DC-SIGN is highly expressed on immature monocyte-derived DCs, with at least 100,000 copies and often in excess of 250,000 copy per DC, which indicates that factors other than DC- SIGN may play important roles in the ability of DCs to capture and transmit HIV.
DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
TLDR
The presence of this efficient virus attachment factor on multiple endothelial cell types indicates that DC-SIGNR could play a role in the vertical transmission of primate lentiviruses, in the enabling of HIV to traverse the capillary endothelium in some organs, and in the presentation of virus to CD4-positive cells in multiple locations including lymph nodes.
cis Expression of DC-SIGN Allows for More Efficient Entry of Human and Simian Immunodeficiency Viruses via CD4 and a Coreceptor
TLDR
DC-SIGN expression can boost virus infection in cis and can expand viral tropism without affecting coreceptor preference, and immunohistochemical and confocal microscopy data indicated that DC-SIGN was coexpressed and colocalized with CD4 and CCR5 on alveolar macrophages, underscoring the physiological significance of these cis enhancement effects.
DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus
TLDR
Investigating the structural determinants of DC-SIGN required for virus binding and transmission to permissive cells found that R5, X4, and R5X4 HIV-1 isolates as well as simian immunodeficiency and HIV-2 strains bound toDC-SIGN and could be transmitted to CD4/coreceptor-positive cell types.
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection.
DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review.
TLDR
A DC-specific C-type lectin that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120 is described that promotes efficient infection in trans of cells that express CD4 and chemokine receptors.
DC-SIGN and DC-SIGNR: helping hands for HIV.
Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques
TLDR
Findings suggest that DC-SIGN+ DCs could play a role in the transmission of primate lentiviruses in the ileum and the rectum whereas accessibility to DC- SIGN+ cells is limited in an intact vaginal mucosa.
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