The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?

  title={The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?},
  author={F. Baribaud and R. Doms and S. P{\"o}hlmann},
  journal={Expert Opinion on Therapeutic Targets},
  pages={423 - 431}
  • F. Baribaud, R. Doms, S. Pöhlmann
  • Published 2002
  • Biology, Medicine
  • Expert Opinion on Therapeutic Targets
  • Sexual transmission of HIV requires that the virus crosses mucosal barriers and disseminates into lymphoid tissue, the major site of viral replication. To achieve this, HIV might engage DC-SIGN, a calcium dependent lectin that is expressed on mucosal dendritic cells (DCs), which binds avidly to HIV. DC-SIGN and other attachment factors are likely to account for the well-known ability of DCs to enhance infection of T cells by HIV. Attachment of HIV to DC-SIGN might thus enhance viral spread in… CONTINUE READING
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