The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study

@inproceedings{Gormley2011TheRO,
  title={The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study},
  author={Julie A. Gormley and Shauna M. Hegarty and Anthony O'Grady and Mark Stevenson and Roberta E. Burden and H L Barrett and Christopher John Scott and J Andrew Johnston and Richard J. Wilson and Elaine W. Kay and Patrick Gerard Johnston and Shane A. Olwill},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:The aim of this pilot retrospective study was to investigate the immunohistochemical expression of Cathepsin S (CatS) in three cohorts of colorectal cancer (CRC) patients (n=560).Methods:Prevalence and association with histopathological variables were assessed across all cohorts. Association with clinical outcomes was investigated in the Northern Ireland Adjuvant Chemotherapy Trial cohort (n=211), where stage II/III CRC patients were randomised between surgery-alone or surgery with… CONTINUE READING