The role of Ca2+ ions in the regulation of intramitochondrial metabolism and energy production in rat heart

@article{McCormack1989TheRO,
  title={The role of Ca2+ ions in the regulation of intramitochondrial metabolism and energy production in rat heart},
  author={James G. McCormack and Richard M. Denton},
  journal={Molecular and Cellular Biochemistry},
  year={1989},
  volume={89},
  pages={121-125}
}
In the heart and other mammalian tissues, there are three exclusively intramitochondrial dehydrogenases that occupy key regulatory sites in oxidative metabolism which can be activated by increases in Ca2+ in the approximate range 0.05–5 μM; they are the pyruvate, NAD+-isocitrate and 2-oxoglutarate dehydrogenases. Activation of these enzymes can be demonstrated within intact mitochondria, incubated under expected physiological conditions, when the extramitochondrial concentration of Ca+ is… CONTINUE READING
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The regulation of mitochondrial calcium transport in heart

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Ca 2+ as a second messenger within mitochondria

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