The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work.

@article{Balaban2009TheRO,
  title={The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work.},
  author={Robert S Balaban},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1787 11},
  pages={1334-41}
}
The heart is capable of balancing the rate of mitochondrial ATP production with utilization continuously over a wide range of activity. This results in a constant phosphorylation potential despite a large change in metabolite turnover. The molecular mechanisms responsible for generating this energy homeostasis are poorly understood. The best candidate for a cytosolic signaling molecule reflecting ATP hydrolysis is Ca(2+). Since Ca(2+) initiates and powers muscle contraction as well as serves as… CONTINUE READING

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