The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel.

@article{Gentile1998TheRO,
  title={The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel.},
  author={Dr. M. Gentile and Carole H J Verhoeven and Tsutomu Shimada and David J. Back},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 3},
  pages={
          975-82
        }
}
Desogestrel is a 3-deoxo progestogenic steroid that requires bioactivation to 3-ketodesogestrel. In these studies we have attempted to define the pathway of 3-ketodesogestrel formation and characterise the enzymes responsible for this biotransformation in vitro. Initial studies using deuterated desogestrel confirmed that desogestrel is metabolised by human liver microsomes via 3alpha-hydroxy and 3beta-hydroxydesogestrel to 3-ketodesogestrel. Metabolites were analysed by radiometric high… CONTINUE READING

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Metabolism of the contraceptive steroid desogestrel by human liver in vitro

  • S Madden, DJ Back, Orme ML’E
  • J Steroid Biochem
  • 1990
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