The role of CYP26 enzymes in retinoic acid clearance.

  title={The role of CYP26 enzymes in retinoic acid clearance.},
  author={Jayne E Thatcher and Nina Isoherranen},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={5 8},
Retinoic acid (RA) is a critical signaling molecule that regulates gene transcription and the cell cycle. Understanding of RA signaling has increased dramatically over the past decades, but the connection between whole body RA homeostasis and gene regulation in individual cells is still unclear. It has been proposed that cytochrome P450 family 26 (CYP26) enzymes have a role in determining the cellular exposure to RA by inactivating RA in cells that do not need RA. The CYP26 enzymes have been… CONTINUE READING

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