The role of CYBA (p22phox) and catalase genetic polymorphisms and their possible epistatic interaction in cervical cancer

@article{Castaldo2014TheRO,
  title={The role of CYBA (p22phox) and catalase genetic polymorphisms and their possible epistatic interaction in cervical cancer},
  author={St{\'e}phanie Ana{\'i}s Castaldo and Alda Pereira da Silva and Andreia Matos and {\^A}ngela In{\'a}cio and Manuel Diamantino Bicho and Rui Medeiros and Irina Alho and Maria Clara Bicho},
  journal={Tumor Biology},
  year={2014},
  volume={36},
  pages={909-914}
}
Human papillomavirus (HPV) infection is necessary but not a sufficient cause for the development of invasive cervical cancer (ICC). Epithelial tissues, target for HPV, are exposed to reactive oxygen species (ROS) associated with tumor initiation and progression. The NADPH oxidase (NOX) and catalase (CAT) are involved in hydrogen peroxide (H2O2) production and inactivation, respectively. P22phox is the NOX subunit encoded by the CYBA gene that has a functional polymorphism (C-242T). This protein… CONTINUE READING
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