The role of CXCR2 in systemic neovascularization of the mouse lung.

@article{Snchez2007TheRO,
  title={The role of CXCR2 in systemic neovascularization of the mouse lung.},
  author={Jes{\'u}s Hern{\'a}ndez-Gil S{\'a}nchez and Aigul Moldobaeva and Jessica Y McClintock and John Christopher Jenkins and Elizabeth Wagner},
  journal={Journal of applied physiology},
  year={2007},
  volume={103 2},
  pages={
          594-9
        }
}
We previously showed increased expression of the ELR+, CXC chemokines in the lung after left pulmonary artery obstruction. These chemokines have been shown in other systems to bind their G protein-coupled receptor, CXCR(2), and promote systemic endothelial cell proliferation, migration, and capillary tube formation. In the present study, we blocked CXCR(2) in vivo using a neutralizing antibody and also studied mice that were homozygous null for CXCR(2). To estimate the extent of… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Inflammation and ischemia-induced lung angiogenesis.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2008
VIEW 8 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Increased hyaluronan fragmentation during pulmonary ischemia.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2011
VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling.

  • American journal of respiratory cell and molecular biology
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Interleukin-8: a very important chemokine of the human airway epithelium.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2002
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Angiogenesis in the mouse lung.

  • The American journal of pathology
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Chemokines. In: The Lung, edited by Crystal RG

R Strieter, SL Kunkel
  • West JB, Barnes PJ, and Weibel ER. Philadelphia: Lippincott-Raven,
  • 1997
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL