The role of CMV inflammatory genes in hearing loss.

  title={The role of CMV inflammatory genes in hearing loss.},
  author={Scott A Schraff and David K Brown and Mark R. Schleiss and Jareen Meinzen-Derr and John H. Greinwald and Daniel I. Choo},
  journal={Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  volume={28 7},
HYPOTHESIS The purpose of this study is to test the hypothesis that virally encoded immunomodulatory genes play a role in cytomegalovirus (CMV)-related hearing loss. OBJECTIVE Cytomegalovirus is the leading cause of infectious-related congenital sensorineural hearing loss worldwide. Unfortunately, little is known about the pathophysiology of CMV-related injury to the developing ear. METHODS Viral mutagenesis techniques were developed that allow the deletion of a specific viral… CONTINUE READING