The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis.

@article{Ariyama2008TheRO,
  title={The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis.},
  author={Yasuyo Ariyama and Yoshito Tanaka and Hiroyuki Shimizu and Kenju Shimomura and Shuichi Okada and Tsugumichi Saito and Eijiro Yamada and Seiichi Oyadomari and Masataka Mori and Masatomo Mori},
  journal={Metabolism: clinical and experimental},
  year={2008},
  volume={57 12},
  pages={1625-35}
}
Low expression of antioxidant enzymes makes pancreatic beta-cells susceptible to cell damage by oxidative stress. Pancreatic beta-cell loss caused by endoplasmic reticulum stress is associated with the onset of diabetes mellitus. The present studies were undertaken to investigate a possible involvement of proapoptotic gene CHOP in pancreatic beta-cells damage by oxidative stress. The induction of CHOP messenger RNA and apoptosis were investigated in betaHC-9 cells after the oxidative stress by… CONTINUE READING

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