The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice.

@article{Borrow1992TheRO,
  title={The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice.},
  author={Persephone Borrow and Paul Tonks and C. Jane Welsh and Anthony Nash},
  journal={The Journal of general virology},
  year={1992},
  volume={73 ( Pt 7)},
  pages={1861-5}
}
The technique of in vivo depletion with T cell subset-specific monoclonal antibodies was used to study the involvement of CD8+T cells in protection/pathogenesis during the acute and chronic demyelinating phases of Theiler's murine encephalomyelitis virus (TMEV)-induced disease. Mice rendered CD8-deficient prior to infection with TMEV were less efficient at clearing virus from the central nervous system compared to intact animals and also suffered demyelinating disease of earlier onset and… CONTINUE READING
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Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease

  • M. BRAC
  • Microbial Pathogenesis
  • 1987

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