The role of CD8+ T cells in immune responses to colorectal cancer

  title={The role of CD8+ T cells in immune responses to colorectal cancer},
  author={Liviu V. Titu and John R. T. Monson and John Greenman},
  journal={Cancer Immunology, Immunotherapy},
Cytotoxic T lymphocytes (CTL) are essential effectors of the cell-mediated immune response. The ability of CTL to specifically recognise and lyse malignant cells expressing the relevant surface antigens under optimal in vitro conditions justifies attempts to boost their number and activity through various forms of immunotherapy. Considering the high prevalence of colorectal cancer and poor survival rates for patients with advanced-stage disease, the development of new protocols based on CTL… CONTINUE READING
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